Tan Sri Mokhzani was formerly a senior official in Kedah UMNO, but has since retired from politics. He is the second eldest son of the former Prime Minister of Malaysia Tun Dr. Mahathir Mohamad. He has been listed as the 14th richest person in Malaysia by Forbes Asia with an estimated net worth of US$685 million in 2012.
He began working in 1987 as a wellsite operations engineer with Sarawak Shell Berhad. In 1989 he left Shell to pursue business opportunities in Kuala Lumpur. Over the course of 5 years, he ventured into the plastics and electronics components manufacturing, oil and gas, finance and healthcare sectors. He held positions as the Group CEO and Executive Chairman in several public listed companies in Malaysia and Singapore, including Tongkah Holding Berhad, Pantai Holdings Berhad and Goldtron Limited.
Following the 1998 Asian Financial Crisis, he undertook a divestment exercise which saw him relinquish all positions and equity in these companies. By 2001, he replenished his portfolio of investments to include businesses in IT, oil and gas support services, structural steel engineering and fabrication, the automotive sector and property development.
He was Group CEO of Kencana Petroleum Berhad and later non-independent Executive Vice-Chairman and Director of SapuraKencana Petroleum Berhad, up to 4 March 2015. He was also the Chairman and Chief Executive Officer of Opcom Holdings Berhad up to 1 June 2019.
Through his family office, Kencana Capital Sdn. Bhd., he maintains investments in IT, property, agriculture and food industry and the automotive sector. He was Chairman of Sepang International Circuit Sdn. Bhd., for 13 years until 2017. He is also President of Motorsports Association of Malaysia, governing body for all FIA, FIM and CIK sanctioned events in Malaysia.